Mark Zarella is the Vice Chair of Digital and Computational Pathology at the University of Pennsylvania. He has been an active participant in the field of digital pathology since 2012. Prior to joining Penn Medicine, he served as the Scientific Director of the Division of Computational Pathology & AI at the Mayo Clinic. Before joining Mayo, he was the Director of Digital Pathology at Johns Hopkins Medicine and the Director of Pathology Informatics at Drexel University. Dr. Zarella has served on the Digital and Computational Pathology Committee for the College of American Pathologists, the Board of Directors for the Digital Pathology Association, and numerous institutional boards related to clinical informatics, AI governance, and high performance computing. His research focus is on establishing and refining best practices to ensure the responsible deployment of AI tools in pathology, which includes establishing novel techniques for quantitative evaluation of AI models to estimate risk.